Not too long ago, nice progress has been made in nanozyme analysis because of the speedy growth of nanomaterials and nanotechnology. MXene-based nanomaterials have gained appreciable consideration owing to their distinctive physicochemical properties. They’ve been discovered to have excessive enzyme-like properties, reminiscent of peroxidase, oxidase, catalase, and superoxide dismutase. On this mini-review, we current an summary of the latest progress in MXene-based nanozymes, with emphasis on their artificial strategies, hybridization, bio-catalytic properties, and biomedical functions. The long run challenges and prospects of MXene-based nanozymes are additionally proposed.